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Under the HCI puffing profile, cigarette delivered 95 g nicotine/puff while the e-cig delivered 60 g/puff at 18 W setting and 137 g/puff at 30 W setting [4] and the mice received 120 puffs per day

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Mechanisms include ovarian dysfunction, altered hormone levels, direct gonadotoxic effects, and genetic damage to sperm from cigarette mutagens (He and Wan 2023

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